Current Research

Articles from the National Institutes of Health

Cannabidiol in Anxiety and Sleep: A Large Case Series

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects

Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis

An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies.

Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract

Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life

Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects

Alcohol Extracts vs CO2 Extracts

Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

​Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells.

​Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome.

Antibacterial cannabinoids from Cannabis sativa: a structure‐activity study.

CBD compound in cannabis could treat diabetes, researchers suggest,-researchers-suggest-95335970.html

Regulation of nausea and vomiting by cannabinoids.

Interaction between non‐psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti‐ nausea or anti‐emetic effects of cannabidiol (CBD) in rats and shrews.

Cannabidiol, a non‐psychotropic component of cannabis, attenuates vomiting and nausea‐like behaviour via indirect agonism of 5‐HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus.

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.

Pure cannabidiol in the treatment of malignant migrating partial seizures in infancy: a case

Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine.

Anti‐inflammatory effects of the cannabidiol derivative dimethylheptyl‐cannabidiol ‐ studies in BV‐2 microglia and encephalitogenic T cells.

Cannabidiol (CBD) and its analogs: a review of their effects on inflammation

Anti‐inflammatory and antioxidant effects of a combination of cannabidiol and moringin in LPS‐stimulated macrophages.

The nonpsychoactive Cannabis constituent cannabidiol is a wake‐inducing agent.

Potential Effects of Cannabidiol as a Wake‐Promoting Agent

Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury.

Cannabidiol as potential anticancer drug

The Antitumor Activity of Plant‐Derived Non‐ Psychoactive Cannabinoids.

Cannabis and Cannabinoids

Cannabinoids inhibit human keratinocyte proliferation through a non‐CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis.

The relationship between cannabidiol and psychosis: A review.

A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation.

Could cannabidiol be used as an alternative to antipsychotics?

Cannabidiol attenuates haloperidol‐induced catalepsy and c‐Fos protein expression in the dorsolateral striatum via 5‐HT1A receptors in mice.

Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects.

A systematic review of the antipsychotic properties of cannabidiol in humans.

Multiple mechanisms involved in the large‐spectrum therapeutic potential of cannabidiol in psychiatric disorders

Cannabidiol Modulates Fear Memory Formation Through Interactions with Serotonergic Transmission in the Mesolimbic System.

Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug.

Endocannabinoid system: Role in depression, reward and pain control (Review).

Beyond the CB1 Receptor: Is Cannabidiol the Answer forDisorders of Motivation?

Does cannabidiol have a role in the treatment of schizophrenia? Cannabinoids and schizophrenia: therapeutic prospects.

The therapeutic potential of the phytocannabinoid cannabidiol for Alzheimer’s disease.

Long‐term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer’s disease transgenic mice.

Evidences for the anti‐panic actions of Cannabidiol.

Purified Cannabidiol, the main non‐psychotropic component of Cannabis sativa, alone, counteracts neuronal apoptosis in experimental multiple sclerosis.

The Profile of Immune Modulation by Cannabidiol (CBD) Involves Deregulation of Nuclear Factor of Activated T Cells (NFAT)

Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells.

CBD & Inflammatory Bowel Disease‐inflammatory‐bowel‐disease

Cannabidiol, a Major Non‐Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts.

CBD‐enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience.

Perceived efficacy of cannabidiol‐enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox‐Gastaut syndrome.

Cannabidiol: Promise and Pitfalls

HU‐446 and HU‐465, Derivatives of the Non‐psychoactive Cannabinoid Cannabidiol, Decrease the Activation of Encephalitogenic T Cells.

A new formulation of cannabidiol in cream shows therapeutic effects in a mouse model of experimental autoimmune encephalomyelitis.

Transdermal cannabidiol reduces inflammation and pain‐ related behaviours in a rat model of arthritis.

Cannabidiol limits Tcell‐mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation.

Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome.

Differential effectiveness of selected non‐psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrheic skin and acne treatment.

Cannabidiol increases survival and promotes rescue of cognitive function in a murine model of cerebral malaria.

Cannabidiol improves lung function and inflammation in mice submitted to LPS‐induced acute lung injury.

Effects of cannabidiol in the treatment of patients with Parkinson’s disease: an exploratory double‐blind trial.